3 AI Agents That Actually Replaced Human Jobs | E2272
April 7, 2026 · 1 h 19 min
🎙️ Full episode
No time for the whole episode?
A debrief is a short AI summary of this episode, written and voiced: the key takeaways, notable quotes, and the moments worth hearing in full. It takes a few minutes to make. Free during the beta, up to 5 new debriefs a week.
Show notes
Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it's going to cost now, and whether this is truly the end of the subsidized AI era.
And they all brought demos! We're checking out ClawChief from Ryan Carson, Alex Finn's agent Henry, and Yazin Alirhayim's Sidecast protocol, inspired by a special request from JCal!
Hosts
Jason Calacanis: http://x.com/jason
Lon Harris: https://x.com/lons
Guests
Ryan Carson: https://x.com/ryancarson
Clawchief: https://github.com/snarktank/clawchief
Alex Finn: https://x.com/AlexFinn
Creator Buddy: https://www.creatorbuddy.io/
Yazin Alirhayim: https://x.com/yazins
OpenOats / Sidecast: https://github.com/yazinsai/OpenOats
Further Reading
The Checklist Manifesto by Atul Gawande: https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000
Marc Andreessen on AI job loss: https://x.com/pmarca/status/2040919227641856307
OpenAI acquires TBPN: https://openai.com/index/openai-acquires-tbpn/
This Week In Startups is made possible by:
Gusto - https://Gusto.com/twist
Vanta - https://vanta.com/twist
Shopify - https://shopify.com/twist
Plaud - https://Plaud.ai/twist
Today's show:
Timestamps:
Welcome back to TWiST
Jason's thinks Andor is as good as Empire Strikes Back…
Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!
Check out the checklist manifesto! https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000
Our guests Ryan Carson, Alex Finn, and Yazin Alirhayim, and join the show
Gusto - Check out the online payroll and benefits experts with software built specifically for small businesses and startups. Try Gusto today and get three months FREE at https://Gusto.com/twist.
People are automating their coworkers and getting them fired…
Anthropic Bans OpenClaw
Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist
How "caveman talk" makes AI works better
Alex thinks $2000/ month subscription plans are inevitable for AI.
Why is nobody using the leaked Anthropic Model?
Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist
Open models have been 6 months behind for the past few years
Why did OpenAI acquire TBPN?
Tactical/ Practical: The product itself is the most important thing
Demo or Die! Yazin is back to show off OpenOats
Ryan's "Claw Chief" https://github.com/snarktank/clawchief/blob/main/skills/executive-assistant/SKILL.md?plain=1
Alex's big announcement, "Henry intelligent machines"
Alex Finn DESTROYS Higgsfield's marketing strategy
Throwback to "Pay Per Post"
Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com
Check out